{"id":79137,"date":"2025-04-18T07:03:20","date_gmt":"2025-04-18T05:03:20","guid":{"rendered":"https:\/\/d14saept1n0koz.cloudfront.net\/science\/"},"modified":"2025-08-08T11:09:54","modified_gmt":"2025-08-08T09:09:54","slug":"science","status":"publish","type":"page","link":"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/science\/","title":{"rendered":"Science"},"content":{"rendered":"    <section class=\"sub-page-banner bg-img\" style=\"background-image:url(https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/08\/08092105\/Science.jpg)\">\n        <div class=\"container content-sec\" role=\"main\" id=\"main\">\n            <nav aria-label=\"breadcrumb\">\n            <ol class=\"breadcrumb\">\n                <li class=\"breadcrumb-item\"><a href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/\">Accueil<\/a><\/li><li class=\"breadcrumb-item active\"><a class=\"link-pointer-events-none\" href=\"#\" aria-current=\"page\">Science<\/a><\/li><\/ol>\n            <\/nav>            <h1 class=\"visible\">Science<\/h1>\n            <p class=\"visible\">Orienter la science vers l\u2019innovation<\/p>\n        <\/div>\n    <\/section>\n\n\n    <section class=\"title-text \">\n        <div class=\"container\">\n            <div class=\"title-text-inner\" style=\"background-color:#EDEBE4;\">\n\n                <!-- If heading is enabled then it's visible -->\n                <div class=\"text-head-dash hidden\">\n                    <h3 class=\"heading-three\">\n                                            <\/h3>\n                <\/div>\n               \n                <!-- If description is enabled then it's visible -->\n                <div class=\"text-parbase visible\">\n                    <p>Chez Ipsen, nous croyons que l\u2019innovation scientifique doit servir un but. Gr\u00e2ce \u00e0 notre taille unique et \u00e0 nos expertises de pointe, Ipsen acc\u00e9l\u00e8re l\u2019innovation en op\u00e9rant avec agilit\u00e9 entre les jalons de d\u00e9veloppement et les processus r\u00e9glementaires pour apporter des m\u00e9dicaments innovants aux patients du monde entier.<\/p>\n                <\/div>\n\n                <!-- If button is enabled then it's visible -->\n                \n            <\/div>\n        <\/div>\n    <\/section>\n\n\n<!--Graphics Cards Carousel Start Here-->\n\n    <section class=\"graphic-card graphics-old-layout bg-color-disabled bg-image-disabled bg-video-disabled bg-mobile-video-img-disabled\"    data-displaycards=\"3\">\n                <div class=\"container\">\n            <div class=\"text-graph-inner\">\n                <div class=\"row\">\n                    <!--Graphic info section-->\n                    <div class=\"column-1 col-xl-12 col-md-12 col-sm-12\">\n                        <div class=\"text-graph-heading\">\n                            <h3 class=\"charcoal-grey visible heading-three\">\n                                Nous apportons l\u2019innovation l\u00e0 o\u00f9 les options sont les plus limit\u00e9es pour les patients                            <\/h3>\n                            <p class=\"text-graph-para charcoal-grey hidden\"><\/p>\n                        <\/div>\n                    <\/div><!--Graphic info section over here -->\n\n                    <!--Graphic detail section-->\n                    <div class=\"column-2 col-xl-12 col-md-12 col-sm-12\">\n                        <!-- graphic-card carousel start here -->\n                                                    <div class=\"text-graph-carousel\">\n                                <div class=\"glider-contain multiple\">\n                                    \n                                <div class=\"glider-graphic-card\" tabindex=\"-1\">\n                                                                                                                        <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                        \n                                                                <!-- Graphic Card With OLD layout start here -->\n                                                                <div class=\"column-1\">\n                                                                                                                                                <div class=\"text-graph-img visible graphic-image-enabled \">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/04\/22093734\/image.png\" alt=\"\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                    <\/div>\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"text-graph-content\">\n                                                                                                                                                        <div class=\"text-graph-title\">\n                                                                                    <h4>Oncologie<\/h4>\n                                                                                <\/div>\n                                                                                                                                                <div class=\"text-graph-desc\">\n                                                                            <p><p>Notre objectif est de fa\u00e7onner l\u2019avenir des traitements contre le cancer en soutenant une vision audacieuse de l\u2019innovation scientifique et en d\u00e9veloppant des traitements novateurs contre les tumeurs complexes et les cancers rares.<br \/>\nEn utilisant des approches centr\u00e9es sur les biomarqueurs, nous faisons progresser la recherche sur des m\u00e9dicaments v\u00e9ritablement diff\u00e9renciants, afin de d\u00e9velopper le meilleur traitements adapt\u00e9 \u00e0 chaque patient.<\/p>\n<\/p>\n                                                                        <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With OLD layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                        \n                                                                <!-- Graphic Card With OLD layout start here -->\n                                                                <div class=\"column-1\">\n                                                                                                                                                <div class=\"text-graph-img visible graphic-image-enabled \">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/16142042\/Mask-group.png\" alt=\"\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                    <\/div>\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"text-graph-content\">\n                                                                                                                                                        <div class=\"text-graph-title\">\n                                                                                    <h4>Maladies rares<\/h4>\n                                                                                <\/div>\n                                                                                                                                                <div class=\"text-graph-desc\">\n                                                                            <p><p>Notre but est d\u2019utiliser la science pour faire la lumi\u00e8re sur des maladies rares, en identifiant des cibles m\u00e9dicamenteuses pr\u00e9cises et en d\u00e9veloppant des m\u00e9dicaments qui modifient l\u2019\u00e9volution de ces maladies et am\u00e9liorent la qualit\u00e9 de vie des patients.<\/p>\n<p>En tirant le meilleur de la recherche translationnelle et en acc\u00e9l\u00e9rant l\u2019innovation, nous nous donnons les moyens de d\u00e9velopper des th\u00e9rapies cibl\u00e9es pour des maladies complexes telles que les maladies cholestatiques rares du foie et les troubles osseux.<\/p>\n<\/p>\n                                                                        <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With OLD layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                        \n                                                                <!-- Graphic Card With OLD layout start here -->\n                                                                <div class=\"column-1\">\n                                                                                                                                                <div class=\"text-graph-img visible graphic-image-enabled \">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/16142046\/Mask-group-1.png\" alt=\"\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                    <\/div>\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"text-graph-content\">\n                                                                                                                                                        <div class=\"text-graph-title\">\n                                                                                    <h4>Neurosciences<\/h4>\n                                                                                <\/div>\n                                                                                                                                                <div class=\"text-graph-desc\">\n                                                                            <p><p>Notre but est de mettre au point des traitements innovants qui am\u00e9liorent et \u00e9tendent les b\u00e9n\u00e9fices procur\u00e9s aux personnes atteintes de maladies invalidantes, pour lesquelles les options s\u2019av\u00e8rent limit\u00e9es.<\/p>\n<p>Ipsen s\u2019appuie sur son expertise dans les toxines, son exp\u00e9rience en neurosciences et ses capacit\u00e9s uniques de d\u00e9veloppement biopharmaceutique pour stimuler l\u2019innovation.<\/p>\n<\/p>\n                                                                        <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With OLD layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                <\/div>\n                            <\/div>\n                                            <\/div> <!-- graphic-card carousel end here -->\n                <\/div> <!--Graphic detail section over here with 12 grid -->   \n            <\/div><!--row ended here-->\n        <\/div> <!-- graph-inner ended here -->\n        \n            <div class=\"more-result-btn\">\n                                            <\/div>\n        <\/div> <!--Container class ended here -->\n    <\/section>\n<!--Graphics Cards Carousel End Here-->\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<h3 class=\"wp-block-heading\">Comment Ipsen fait avancer la science avec d\u00e9termination<\/h3>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/20074009\/IPSEN_250226_SCIENCE-2_oncology-RVB-V2-1-4.png\" \n                                    alt=\"Les efforts de recherche d\u2019Ipsen dans les ADC\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\">\n                                    Les efforts de recherche d\u2019Ipsen dans les ADC                                <\/h4>\n                                                    <\/div>\n                                                        <p class=\"section-head-two heading-para\">\n                                    Atteindre l\u2019\u00e9quilibre avec pr\u00e9cision                                <\/p>\n                                                <p>Nous avons pour objectif premier de maximiser le potentiel des trois composants cl\u00e9s des ADC dans les tumeurs solides : l\u2019anticorps monoclonal, l\u2019agent cytotoxique et la mol\u00e9cule de liaison.<\/p>\n<p>En ciblant les antig\u00e8nes sp\u00e9cifiques des tumeurs avec des associations agent cytotoxique \u2013 mol\u00e9cule de liaison innovante et avec un rapport m\u00e9dicament cytotoxiques\/anticorps (DAR) \u00e9lev\u00e9, nous visons \u00e0 obtenir une forte activit\u00e9 antitumorale sur diverses tumeurs solides, tout en conservant des profils de tol\u00e9rance prometteurs.<\/p>\n                            <a \n                            aria-label=\" opens in new tab\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner section-reverse\">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row section-reverse\">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/20074039\/IPSEN_250226_SCIENCE-2_oncology-RVB-V2-1-5.png\" \n                                    alt=\"Les efforts de recherche d\u2019Ipsen dans la voie MAPK\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\">\n                                    Les efforts de recherche d\u2019Ipsen dans la voie MAPK                                <\/h4>\n                                                    <\/div>\n                                                        <p class=\"section-head-two heading-para\">\n                                    Nous suivons la science pour mieux cibler la tumeur                                <\/p>\n                                                <p>Nos \u00e9quipes d\u2019experts \u00e9tudient des moyens de bloquer plus efficacement la voie MAPK \u00e0 plusieurs points, en relevant des d\u00e9fis tels que la r\u00e9activation et la r\u00e9sistance de la voie.<\/p>\n<p>Nous cherchons \u00e0 exploiter le potentiel de diversit\u00e9 de la voie MAPK en ciblant diff\u00e9rentes prot\u00e9ines, sur plusieurs types de tumeurs solides, et utilisons la m\u00e9thode d\u2019identification des mutations bas\u00e9e sur des biomarqueurs pour trouver les patients qui en b\u00e9n\u00e9ficieront le plus.<\/p>\n<p>Fort d\u2019un processus d\u00e9cisionnel fond\u00e9 sur les donn\u00e9es et de notre engagement ind\u00e9fectible \u00e0 traiter certain des cancers les plus complexes, nous poursuivons l\u2019objectif de d\u00e9velopper des th\u00e9rapies cibl\u00e9es qui am\u00e9lioreront les r\u00e9sultats des patients.<\/p>\n                            <a \n                            aria-label=\" opens in new tab\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/20074114\/IPSEN_250226_SCIENCE-2_oncology-RVB-V2-1-6.png\" \n                                    alt=\"Les efforts de recherche d\u2019Ipsen dans les TCE\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\">\n                                    Les efforts de recherche d\u2019Ipsen dans les TCE                                <\/h4>\n                                                    <\/div>\n                                                        <p class=\"section-head-two heading-para\">\n                                    Mettre la science au service de la lutte contre le cancer                                <\/p>\n                                                <p>Forts de notre approche bas\u00e9e sur les donn\u00e9es scientifiques, nous d\u00e9veloppons diff\u00e9rentes strat\u00e9gies pour trouver de nouvelle mani\u00e8re d\u2019engager les lymphocytes T, permettant de surmonte les d\u00e9fis li\u00e9s la toxicit\u00e9s et l\u2019\u00e9puisement fonctionnel des lymphocytes T qui ne sont alors plus en mesure d\u2019assurer correctement leur r\u00f4le.<\/p>\n<p>Gr\u00e2ce \u00e0 des connaissances bas\u00e9es sur les biomarqueurs et \u00e0 la conception de plateformes de nouvelle g\u00e9n\u00e9ration, nous nous effor\u00e7ons d\u2019\u00e9tendre le potentiel des ces nouveaux m\u00e9dicaments \u00e0 un large \u00e9ventail de cancers, y compris les tumeurs dites  froides typiquement moins sensible \u00e0 l\u2019immunoth\u00e9rapie.<\/p>\n<p>En tirant parti d\u2019innovations r\u00e9volutionnaires, telles que la redirection et l\u2019expansion de lymphocytes T hautement actifs, nous entendons red\u00e9finir la mani\u00e8re dont les immunoth\u00e9rapies exploitent le syst\u00e8me immunitaire. Appuy\u00e9s par la science et constamment engag\u00e9s envers les personnes confront\u00e9es \u00e0 certains des cancers les plus difficiles \u00e0 traiter, nous soutenons le d\u00e9veloppement de traitements plus pr\u00e9cis, plus efficaces et plus s\u00fbrs pour ceux qui en ont le plus besoin.<\/p>\n                            <a \n                            aria-label=\" opens in new tab\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:1000%\"><!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner section-reverse\">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row section-reverse\">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/20074137\/IPSEN_250226_SCIENCE-2_oncology-RVB-V2-1-7.png\" \n                                    alt=\"Recherche dans les maladies cholestatiques rares du foie\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\">\n                                    Recherche dans les maladies cholestatiques rares du foie                                <\/h4>\n                                                    <\/div>\n                                                        <p class=\"section-head-two heading-para\">\n                                    R\u00e9tablir l\u2019\u00e9quilibre gr\u00e2ce \u00e0 la science                                <\/p>\n                                                <p>Notre objectif est d\u2019\u00e9largir les perspectives th\u00e9rapeutiques des patients atteints de maladies h\u00e9patiques rares, pour lesquelles les options actuelles restent limit\u00e9es.<\/p>\n<p>Nous concentrons nos efforts sur cinq maladies rares du foie : SAG, l\u2019AVB, la CBP, la CIFP, et la CSP. L\u2019objectif est de r\u00e9tablir l\u2019\u00e9quilibre biliaire en modulant trois r\u00e9cepteurs diff\u00e9rents impliqu\u00e9s dans le syst\u00e8me des acides biliaires pour soulager les sympt\u00f4mes invalidants et am\u00e9liorer la sant\u00e9 du foie \u00e0 long terme.<\/p>\n<p>Les inhibiteurs de l\u2019IBAT et de l\u2019ASBT r\u00e9duisent la r\u00e9absorption des acides biliaires dans l\u2019intestin, limitant ainsi l\u2019accumulation de bile toxique qui contribue au prurit et aux l\u00e9sions h\u00e9patiques. Les agonistes PPAR activent les r\u00e9cepteurs des cellules h\u00e9patiques pour r\u00e9guler le m\u00e9tabolisme des acides biliaires, r\u00e9duire l\u2019inflammation et contribuer \u00e0 prot\u00e9ger les patients de la progression de la maladie.<\/p>\n<p>Notre engagement va au-del\u00e0 du soulagement des sympt\u00f4mes : nous cherchons \u00e0 r\u00e9aliser des avanc\u00e9es qui redessinent l\u2019avenir du traitement et red\u00e9finissent le champ des possibles pour les personnes atteintes de maladies h\u00e9patiques rares.<\/p>\n                            <a \n                            aria-label=\" opens in new tab\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n<\/div>\n\n\n\n    <!--Accordion Cards Start Here-->\n    <section class=\"accordion bg-color-disabled\"  data-according-id=\"1833220499\">\n        <div class=\"container\">\n            <div class=\"row\">\n                <!--Accordion info section-->\n                <div class=\"column-1 col-xl-12 col-md-12 col-sm-12\">\n                    <div class=\"accordian-info\">\n                        <h3 class=\"accordian-heading visible heading-three\">\n                            Glossaire                        <\/h3>\n                        <p class=\"accordian-summary visible\">Voici quelques termes cl\u00e9s de nos travaux scientifiques et leurs d\u00e9finitions pour mieux les comprendre. \r\n<\/p>\n                    <\/div>\n                <\/div><!--Accordion info section over here -->\n\n                <div class=\"col-xl-12 col-lg-12 col-md-12 col-sm-12\">\n                    <div class=\"accordion accor-group\" id=\"accordionExample1833220499\">\n                         \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading0\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204990\" aria-expanded=\"false\" aria-controls=\"expHeading18332204990\">\n                                                Les conjugu\u00e9s anticorps-m\u00e9dicaments (ADCs)                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204990\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading0\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Les conjugu\u00e9s anticorps-m\u00e9dicaments (ADC) sont des th\u00e9rapies cibl\u00e9es contre le cancer qui associent la pr\u00e9cision des anticorps monoclonaux \u00e0 la puissance d&rsquo;un m\u00e9dicament cytotoxique con\u00e7u pour tuer les cellules canc\u00e9reuses.<\/p>\n<p>Con\u00e7us pour d\u00e9livrer s\u00e9lectivement des agents de chimioth\u00e9rapie aux cellules canc\u00e9reuses tout en pr\u00e9servant les tissus sains, les ADC contribuent \u00e0 minimiser les effets secondaires et \u00e0 am\u00e9liorer l\u2019efficacit\u00e9 du traitement.<\/p>\n<p>En d\u00e9pit des derni\u00e8res avanc\u00e9es, il est difficile, pour de nombreux ADC, d\u2019atteindre l\u2019efficacit\u00e9 tout en maintenant un profil de tol\u00e9rance acceptable.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading1\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204991\" aria-expanded=\"false\" aria-controls=\"expHeading18332204991\">\n                                                Agonisme                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204991\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading1\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Un agoniste est un m\u00e9dicament ou une mol\u00e9cule qui active un r\u00e9cepteur dans le corps, afin de d\u00e9clencher une r\u00e9ponse.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading2\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204992\" aria-expanded=\"false\" aria-controls=\"expHeading18332204992\">\n                                                Anticorps vs antig\u00e8ne                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204992\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading2\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Un anticorps se lie \u00e0 un antig\u00e8ne sp\u00e9cifique, g\u00e9n\u00e9ralement une prot\u00e9ine associ\u00e9e \u00e0 une maladie comme un marqueur du cancer (Similaire \u00e0 une serrure et une cl\u00e9). Un anticorps monoclonal est un anticorps con\u00e7u pour un usage th\u00e9rapeutique.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading3\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204993\" aria-expanded=\"false\" aria-controls=\"expHeading18332204993\">\n                                                Inhibition                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204993\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading3\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Si une voie ou un r\u00e9cepteur joue un r\u00f4le dans le d\u00e9veloppement d\u2019une maladie, il est possible de l\u2019inhiber ou de le bloquer pour r\u00e9duire son activit\u00e9 et ainsi produire un effet th\u00e9rapeutique.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading4\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204994\" aria-expanded=\"false\" aria-controls=\"expHeading18332204994\">\n                                                La voie MAPK                                             <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204994\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading4\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>La voie de signalisation cellulaire MAPK, \u00e9galement appel\u00e9e voie MAP-kinase, joue un r\u00f4le cl\u00e9 dans la r\u00e9gulation de la croissance, de la diff\u00e9renciation et de la prolif\u00e9ration cellulaires. Des mutations dans cette cha\u00eene de prot\u00e9ines peuvent entra\u00eener une hyperactivation de la voie, qui reste alors bloqu\u00e9e dans un \u00e9tat actif.<\/p>\n<p>Les signaux de prolif\u00e9ration cellulaire incontr\u00f4l\u00e9s peuvent entra\u00eener une oncogen\u00e8se, c.-\u00e0-d. que les cellules saines se transforment alors en cellules canc\u00e9reuses.<\/p>\n<p>L\u2019implication de la voie MAPK dans de nombreux types de tumeurs solides en fait une cible th\u00e9rapeutique prometteuse. Diverses strat\u00e9gies ont \u00e9t\u00e9 test\u00e9es pour inhiber les composantes de la voie, avec des succ\u00e8s mais \u00e9galement des d\u00e9fis.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading5\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204995\" aria-expanded=\"false\" aria-controls=\"expHeading18332204995\">\n                                                Nouvelle modalit\u00e9                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204995\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading5\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Nouvelle approche th\u00e9rapeutique offrant une mani\u00e8re diff\u00e9rente de traiter la maladie, en introduisant un m\u00e9canisme ou une strat\u00e9gie de traitement fondamentalement distincte des options existantes.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading6\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204996\" aria-expanded=\"false\" aria-controls=\"expHeading18332204996\">\n                                                Les maladies h\u00e9patiques rares                                             <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204996\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading6\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Le foie joue un r\u00f4le vital dans le bon fonctionnement de l&rsquo;organisme, notamment la <b>production de bile<\/b>, qui facilite la digestion et l\u2019\u00e9limination des d\u00e9chets. La bile circule dans un r\u00e9seau de canaux jusqu\u2019\u00e0 l\u2019intestin gr\u00eale, ou est stock\u00e9e dans la v\u00e9sicule biliaire. La plupart des acides biliaires sont ensuite r\u00e9absorb\u00e9s et retournent au foie, maintenant ainsi l\u2019\u00e9quilibre des acides biliaires de l\u2019organisme.<\/p>\n<p>Les maladies cholestatiques rares du foie (la \u00ab cholestase \u00bb signifie l\u2019alt\u00e9ration du flux biliaire) surviennent lorsque l\u2019\u00e9quilibre est perturb\u00e9, entra\u00eenant une accumulation d\u2019acide biliaire, une toxicit\u00e9, des d\u00e9mangeaisons intenses (prurit), une fatigue extr\u00eame et des l\u00e9sions h\u00e9patiques2. Elles trouvent leur origine dans des mutations g\u00e9n\u00e9tiques, des r\u00e9ponses auto-immunes ou des anomalies structurelles, influant sur leur progression chez l\u2019enfant et l\u2019adulte atteints.<\/p>\n<p>Nous concentrons nos efforts sur cinq maladies rares du foie : le SAG, l\u2019AVB, la CBP, la CIFP et la CSP.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading7\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204997\" aria-expanded=\"false\" aria-controls=\"expHeading18332204997\">\n                                                R\u00e9cepteur                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204997\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading7\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Prot\u00e9ine \u00e0 l\u2019int\u00e9rieur ou \u00e0 la surface d\u2019une cellule qui d\u00e9tecte les signaux du corps ou des m\u00e9dicaments, et d\u00e9clenche une r\u00e9ponse sp\u00e9cifique.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading8\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204998\" aria-expanded=\"false\" aria-controls=\"expHeading18332204998\">\n                                                Administration cibl\u00e9e ou activation immunitaire                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204998\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading8\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Le traitement consiste \u00e0 guider les m\u00e9dicaments directement vers les cellules malades ou \u00e0 am\u00e9liorer la r\u00e9ponse immunitaire de l\u2019organisme.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p class=\"accordion-header accor-head-para\" id=\"expHeading9\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading18332204999\" aria-expanded=\"false\" aria-controls=\"expHeading18332204999\">\n                                                T cell engagers (TCE)                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading18332204999\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading9\" data-bs-parent=\"#accordionExample1833220499\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><p>Les anticorps engageant les lymphocytes T sont une classe d\u2019immunoth\u00e9rapie con\u00e7ue pour exploiter le syst\u00e8me immunitaire \u2013 en particulier les lymphocytes T \u2013 de mani\u00e8re \u00e0 reconna\u00eetre et d\u00e9truire les cellules canc\u00e9reuses.<\/p>\n<p>Ces anticorps sp\u00e9cialement con\u00e7us fonctionnent comme des ponts mol\u00e9culaires, rapprochant deux types cellulaires, notamment une cellule canc\u00e9reuse et un lymphocyte T capable de la d\u00e9truire.<\/p>\n<p>Si les TCE offrent une approche polyvalente et puissante du traitement du cancer, les th\u00e9rapies existantes se confrontent \u00e0 certaines difficult\u00e9s telles que la r\u00e9sistance au traitement et les effets sur d&rsquo;autres cellules que les cellules cibles.<\/p>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                                                <\/div>\n                <\/div> \n            <\/div>\n        <\/div>\n    <\/section>\n    <!--Accordion Cards End Here-->\n\n\n\n<!--Regular card with carousel -->\n<section class=\"p-slider  bg-color-disabled \"  >\n      <div class=\"slider-heading-container\">\n          <h3 class=\"slider-title visible heading-three\">Comment la science donne du sens <\/h3>\n          <p class=\"charcoal-grey visible\"><\/p>\n      <\/div>\n                <!-- glider insert -->\n          <div class=\"glider-contain multiple\">\n                              <!-- buttons -->\n                <div class=\"slider-btns\">\n                    <button aria-label=\"Pr\u00e9c\u00e9dent\" aria-labelledby=\"glider-product-prev\" role=\"button\" title=\"Pr\u00e9c\u00e9dent\" class=\"glider-product-prev\">\n                      <span style=\"background-image:url(https:\/\/d14saept1n0koz.cloudfront.net\/wp-content\/themes\/ipsen-main\/dist\/images\/blue-left-arrow.png);\"><\/span>\n                    <\/button>\n                    <button aria-label=\"Suivant\" aria-labelledby=\"glider-product-next\" role=\"button\" title=\"Suivant\" class=\"glider-product-next\">\n                      <span style=\"background-image:url(https:\/\/d14saept1n0koz.cloudfront.net\/wp-content\/themes\/ipsen-main\/dist\/images\/blue-right-arrow.png);\"><\/span>\n                    <\/button>\n                <\/div>\n                          <div class=\"glider-product\">\n                                      <!-- product box-featured story listing -->\n                        <div class=\"product-box\" data-id=\"27801\">\n                          <!-- img-container -->\n                            <div class=\"p-img-container\">\n                                <div class=\"p-img\">\n                                  <a href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/rare-diseases-fr\/vie-ma-vie-avec-ma-fop-de-lempathie-a-la-comprehension\/\" aria-label=\"Vie ma Vie avec ma FOP : de l\u2019empathie \u00e0 la compr\u00e9hension\u2026\" >\n                                                                              <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2022\/11\/05100048\/Image-1024x768-1.jpeg\" alt=\"Vie ma Vie avec ma FOP : de l\u2019empathie \u00e0 la compr\u00e9hension\u2026\">\n                                                                      <\/a>\n                                <\/div>\n                          <\/div>\n                          <!-- text-container -->\n                          <div class=\"p-box-text\">\n                                                            <button class=\"btn-link card-btn visible\" style=\"background-color:#c84874;\" tabindex=\"-1\">\n                                  Maladies Rares                                <\/button>\n                                                        <span class=\"time-stamp visible\">03 novembre 2022<\/span>\n                            <span class=\"time-stamp visible\">5 \u00a0mn de lecture<\/span>\n                            <div class=\"text-div\">\n                                <a tabindex=\"-1\" aria-label=\"Vie ma Vie avec ma FOP : de l\u2019empathie \u00e0 la compr\u00e9hension\u2026\" href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/rare-diseases-fr\/vie-ma-vie-avec-ma-fop-de-lempathie-a-la-comprehension\/\">\n                                    <p class=\"text-div-para text-underline\">Vie ma Vie avec ma FOP : de l\u2019empathie \u00e0 la compr\u00e9hension\u2026<\/p>\n                                <\/a>\n                                <p>Vous ne pouvez jamais vraiment comprendre ce que c\u2019est que de vivre avec une maladie ultra-rare \u00e0 moins de l\u2019avoir v\u00e9cue par vous-m\u00eame. Et dans&#8230;<\/p>\n                            <\/div>\n                          <\/div>\n                        <\/div>\n                                      <!-- product box-featured story listing -->\n                        <div class=\"product-box\" data-id=\"27805\">\n                          <!-- img-container -->\n                            <div class=\"p-img-container\">\n                                <div class=\"p-img\">\n                                  <a href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/financial-results-fr\/un-mot-de-david-loew-directeur-general\/\" aria-label=\"Un mot de David Loew, Directeur G\u00e9n\u00e9ral\" >\n                                                                              <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2022\/10\/05100901\/202105_Images_346x346pix_1-1.jpeg\" alt=\"Un mot de David Loew, Directeur G\u00e9n\u00e9ral\">\n                                                                      <\/a>\n                                <\/div>\n                          <\/div>\n                          <!-- text-container -->\n                          <div class=\"p-box-text\">\n                                                            <button class=\"btn-link card-btn visible\" style=\"background-color:#5d6265;\" tabindex=\"-1\">\n                                  G\u00e9n\u00e9ral                                <\/button>\n                                                        <span class=\"time-stamp visible\">27 octobre 2022<\/span>\n                            <span class=\"time-stamp visible\">1 \u00a0mn de lecture<\/span>\n                            <div class=\"text-div\">\n                                <a tabindex=\"-1\" aria-label=\"Un mot de David Loew, Directeur G\u00e9n\u00e9ral\" href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/financial-results-fr\/un-mot-de-david-loew-directeur-general\/\">\n                                    <p class=\"text-div-para text-underline\">Un mot de David Loew, Directeur G\u00e9n\u00e9ral<\/p>\n                                <\/a>\n                                <p>\u00ab Je suis fier de la performance d\u2019Ipsen depuis le d\u00e9but de l\u2019ann\u00e9e alors que nous continuons de d\u00e9livrer de solides performances commerciales. \u00bb&nbsp;David Loew,&#8230;<\/p>\n                            <\/div>\n                          <\/div>\n                        <\/div>\n                                      <!-- product box-featured story listing -->\n                        <div class=\"product-box\" data-id=\"27819\">\n                          <!-- img-container -->\n                            <div class=\"p-img-container\">\n                                <div class=\"p-img\">\n                                  <a href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/rare-diseases-fr\/a-life-in-a-day-le-quotidien-des-patients-atteints-de-fop\/\" aria-label=\"\u00ab A Life in a Day \u00bb : le quotidien des patients atteints de FOP\" >\n                                                                              <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2022\/09\/05101525\/Abbie-and-family.jpg\" alt=\"\u00ab A Life in a Day \u00bb : le quotidien des patients atteints de FOP\">\n                                                                      <\/a>\n                                <\/div>\n                          <\/div>\n                          <!-- text-container -->\n                          <div class=\"p-box-text\">\n                                                            <button class=\"btn-link card-btn visible\" style=\"background-color:#c84874;\" tabindex=\"-1\">\n                                  Maladies Rares                                <\/button>\n                                                        <span class=\"time-stamp visible\">05 septembre 2022<\/span>\n                            <span class=\"time-stamp visible\">6 \u00a0mn de lecture<\/span>\n                            <div class=\"text-div\">\n                                <a tabindex=\"-1\" aria-label=\"\u00ab A Life in a Day \u00bb : le quotidien des patients atteints de FOP\" href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/rare-diseases-fr\/a-life-in-a-day-le-quotidien-des-patients-atteints-de-fop\/\">\n                                    <p class=\"text-div-para text-underline\">\u00ab A Life in a Day \u00bb : le quotidien des patients atteints de FOP<\/p>\n                                <\/a>\n                                <p>J\u2019ai \u00e9t\u00e9 honor\u00e9e d\u2019\u00eatre invit\u00e9e \u00e0 relever le d\u00e9fi de vivre durant une journ\u00e9e le quotidien d\u2019un patient atteint de FOP (\u00ab&nbsp;A Life in a&#8230;<\/p>\n                            <\/div>\n                          <\/div>\n                        <\/div>\n                                      <!-- product box-featured story listing -->\n                        <div class=\"product-box\" data-id=\"27828\">\n                          <!-- img-container -->\n                            <div class=\"p-img-container\">\n                                <div class=\"p-img\">\n                                  <a href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/general-fr\/un-mot-de-david-loew-directeur-general-2\/\" aria-label=\"Un mot de David Loew, Directeur G\u00e9n\u00e9ral\" >\n                                                                              <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2022\/10\/05100901\/202105_Images_346x346pix_1-1.jpeg\" alt=\"Un mot de David Loew, Directeur G\u00e9n\u00e9ral\">\n                                                                      <\/a>\n                                <\/div>\n                          <\/div>\n                          <!-- text-container -->\n                          <div class=\"p-box-text\">\n                                                            <button class=\"btn-link card-btn visible\" style=\"background-color:#5d6265;\" tabindex=\"-1\">\n                                  G\u00e9n\u00e9ral                                <\/button>\n                                                        <span class=\"time-stamp visible\">28 juillet 2022<\/span>\n                            <span class=\"time-stamp visible\">1 \u00a0mn de lecture<\/span>\n                            <div class=\"text-div\">\n                                <a tabindex=\"-1\" aria-label=\"Un mot de David Loew, Directeur G\u00e9n\u00e9ral\" href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/general-fr\/un-mot-de-david-loew-directeur-general-2\/\">\n                                    <p class=\"text-div-para text-underline\">Un mot de David Loew, Directeur G\u00e9n\u00e9ral<\/p>\n                                <\/a>\n                                <p>D\u00e9couvrez les commentaires du Directeur g\u00e9n\u00e9ral d\u2019Ipsen David Loew sur les r\u00e9sultats du Groupe au premier semestre 2022.<\/p>\n                            <\/div>\n                          <\/div>\n                        <\/div>\n                                      <!-- product box-featured story listing -->\n                        <div class=\"product-box\" data-id=\"29419\">\n                          <!-- img-container -->\n                            <div class=\"p-img-container\">\n                                <div class=\"p-img\">\n                                  <a href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/general-fr\/les-candidatures-pour-ledition-2023-du-golden-ticket-sont-ouvertes\/\" aria-label=\"Les candidatures pour l\u2019\u00e9dition 2023 du \u00ab Golden Ticket \u00bb sont ouvertes\" >\n                                                                              <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2023\/03\/12172418\/Les-Ulis-France-img-04-none-2-1.jpg\" alt=\"Les candidatures pour l\u2019\u00e9dition 2023 du \u00ab Golden Ticket \u00bb sont ouvertes\">\n                                                                      <\/a>\n                                <\/div>\n                          <\/div>\n                          <!-- text-container -->\n                          <div class=\"p-box-text\">\n                                                            <button class=\"btn-link card-btn visible\" style=\"background-color:#5d6265;\" tabindex=\"-1\">\n                                  G\u00e9n\u00e9ral                                <\/button>\n                                                        <span class=\"time-stamp visible\">23 mai 2023<\/span>\n                            <span class=\"time-stamp visible\">2 \u00a0mn de lecture<\/span>\n                            <div class=\"text-div\">\n                                <a tabindex=\"-1\" aria-label=\"Les candidatures pour l\u2019\u00e9dition 2023 du \u00ab Golden Ticket \u00bb sont ouvertes\" href=\"https:\/\/d14saept1n0koz.cloudfront.net\/fr\/general-fr\/les-candidatures-pour-ledition-2023-du-golden-ticket-sont-ouvertes\/\">\n                                    <p class=\"text-div-para text-underline\">Les candidatures pour l\u2019\u00e9dition 2023 du \u00ab Golden Ticket \u00bb sont ouvertes<\/p>\n                                <\/a>\n                                <p>Dans le cadre de notre engagement \u00e0 acc\u00e9l\u00e9rer l\u2019innovation, nous avons le plaisir d\u2019annoncer que notre concours \u00ab&nbsp;Golden Ticket\u00bb est d\u00e9sormais ouvert aux candidatures&nbsp;! Gr\u00e2ce&#8230;<\/p>\n                            <\/div>\n                          <\/div>\n                        <\/div>\n                                      <!-- product box-featured story listing -->\n                        <div class=\"product-box\" data-id=\"37468\">\n                          <!-- img-container -->\n                            <div class=\"p-img-container\">\n                                <div class=\"p-img\">\n                                  <a href=\"https:\/\/d14saept1n0koz.cloudfront.net\/rare-diseases\/advancing-primary-biliary-cholangitis-pbc-management-insights-from-experts\/\" aria-label=\"Advancing Primary Biliary Cholangitis (PBC) Management: Insights from Experts\u00a0\" >\n                                                                              <img decoding=\"async\" src=\"https:\/\/d14saept1n0koz.cloudfront.net\/wp-content\/uploads\/2023\/11\/13182557\/Boulogne-France-img-17-S-1-1.png\" alt=\"Advancing Primary Biliary Cholangitis (PBC) Management: Insights from Experts\u00a0\">\n                                                                      <\/a>\n                                <\/div>\n                          <\/div>\n                          <!-- text-container -->\n                          <div class=\"p-box-text\">\n                                                            <button class=\"btn-link card-btn visible\" style=\"background-color:#224a81;\" tabindex=\"-1\">\n                                  Rare Disease                                <\/button>\n                                                        <span class=\"time-stamp visible\">11 ao\u00fbt 2023<\/span>\n                            <span class=\"time-stamp visible\">2 \u00a0mn de lecture<\/span>\n                            <div class=\"text-div\">\n                                <a tabindex=\"-1\" aria-label=\"Advancing Primary Biliary Cholangitis (PBC) Management: Insights from Experts\u00a0\" href=\"https:\/\/d14saept1n0koz.cloudfront.net\/rare-diseases\/advancing-primary-biliary-cholangitis-pbc-management-insights-from-experts\/\">\n                                    <p class=\"text-div-para text-underline\">Advancing Primary Biliary Cholangitis (PBC) Management: Insights from Experts\u00a0<\/p>\n                                <\/a>\n                                <p>\u201cWe are on the cusp of an absolute explosion in our approach to managing PBC.\u201d \u2013 Professor Gideon Hirschfield, Hepatologist and Professor of Medicine at&#8230;<\/p>\n                            <\/div>\n                          <\/div>\n                        <\/div>\n                          <\/div>\n          <\/div>\n\n     \n      <div class=\"cta-block hidden\">\n                <\/div>\n  <\/section>\n\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/20074308\/IPSEN_250226_SCIENCE-2_oncology-RVB-V2-1-8.png\" \n                                    alt=\"NOS PARTENARIATS\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\">\n                                    NOS PARTENARIATS                                <\/h4>\n                                                    <\/div>\n                                                <p>Chez Ipsen, nous pensons que les partenariats cr\u00e9ent des possibilit\u00e9s. Nous cherchons \u00e0 \u00e9tablir des partenariats qui renforcent notre capacit\u00e9 \u00e0 am\u00e9liorer ou \u00e0 prolonger la vie des personnes atteintes de cancer, de maladies rares ou d\u2019affections neurologiques.<\/p>\n                            <a \n                            aria-label=\"En savoir plus                   opens in new tab\"  \n                                role=\"link\" \n                                class=\"btn-link section-btn cta-visible\"\n                                href=\"https:\/\/www.ipsen.com\/partnering\/\" \n                                target=\"_blank\"\n                            > \n                                En savoir plus                   \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner section-reverse\">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row section-reverse\">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2025\/05\/20074306\/IPSEN_250226_SCIENCE-2_oncology-RVB-V2-1-9.png\" \n                                    alt=\"ESSAIS CLINIQUES\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\">\n                                    ESSAIS CLINIQUES                                <\/h4>\n                                                    <\/div>\n                                                <p>Ipsen m\u00e8ne des essais cliniques pour faire avancer la science et apporter de nouvelles options innovantes aux patients. Notre r\u00e9seau mondial de professionnels de la sant\u00e9, ainsi que des volontaires et des patients, nous aident \u00e0 tester des m\u00e9dicaments et \u00e0 garantir leur efficacit\u00e9 et leur s\u00e9curit\u00e9 dans le cadre d\u2019essais cliniques avant que de nouveaux traitements puissent \u00eatre approuv\u00e9s et mis \u00e0 disposition du plus grand nombre.<\/p>\n                            <a \n                            aria-label=\"En savoir plus  opens in new tab\"  \n                                role=\"link\" \n                                class=\"btn-link section-btn cta-visible\"\n                                href=\"https:\/\/www.ipsen.com\/clinical-trials\/\" \n                                target=\"_blank\"\n                            > \n                                En savoir plus  \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-79137","page","type-page","status-publish","hentry","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - 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